Good Vaccine Needs Match With Good Ganoderma Lucidum

Good Vaccine Needs Match With Good Ganoderma Lucidum

Good Vaccine Needs Match With Good Ganoderma Lucidum in order to enhance immunity in an all-round way

Ganoderma lucidum Extract can be used to strengthen the deficiency of vaccine

We thought that once the vaccine came out, the problem would be solved. But now we know that even if we have a vaccine, we may not be able to get it.Even if we can, we can’t guarantee that we won’t be infected from now on, because no matter how good the vaccine is, its protection will not be 100%.What’s more, the vaccine is highly specific. When it comes to the so-called “mutant virus”, it is difficult to maintain its original efficacy.

When the virus mutates more than the original vaccine can grasp, a new vaccine is needed to cope with it. However, in the past year, the whole mankind has gone through the development of new vaccines from scratch, and should be able to understand the difficulties of vaccine research and development.In the face of the inevitable protection gap of the vaccine itself and the change of the virus, the last line of defense you can rely on is your own immune system.

More importantly, the key to the effect of the vaccine on you is whether your immune system can be activated by the vaccine. If the immune system itself is an old and weak soldier, then if you want to rely on vaccines to help train the immune system, you may not be able to do so.In other words, to fight back the invisible virus, no matter whether there is a vaccine or not, and no matter how effective the vaccine is, the most important thing is one’s own immunity.

The problem is that our immune system is not only affected by our innate constitution, but also by age, mood, nutrition, stress, overwork and air pollution.So the immune system is like a horse in need of care. It’s too optimistic to think that a horse can grow well without eating grass. If you want a horse to grow well, you need to use “good grass” to feed it. It’s a pragmatic and down-to-earth approach. And the polysaccharide from ganoderma is the “good grass” that can make the immune system a horse into a horse.

 

Ganoderma lucidum polysaccharide enhanced immunity only after it was found anti-tumor

“Ganoderma lucidum polysaccharides enhance immunity” is not COVID-19’s outbreak after the sale of words, but a basic consensus that domestic and foreign scientists accumulated fifty years of research results.

Ganoderma lucidum polysaccharide is the main component of Ganoderma lucidum cell wall. When we decoct Ganoderma slices with water, or extract the fruiting entities by water extraction process, or the wall shell of Ganoderma lucidum spores powder, there are these polysaccharides.

The first time, scientists found that Ganoderma lucidum extract powder by water can inhibit tumor growth in animals, and then further found that the original anti-tumor activity of Ganoderma lucidum extract mainly comes from “Ganoderma lucidum polysaccharide”. The report was published in 1971, when there was a preliminary analysis of its main chemical structure.

In the next two decades, various research reports on the antitumor effect of Ganoderma lucidum polysaccharides were published. However, the antitumor mechanism of Ganoderma lucidum polysaccharides was still unclear, because the combination of Ganoderma lucidum polysaccharides and cancer cells in vitro could not kill cancer cells.

It was not until 1997 that scientists discovered that Ganoderma lucidum polysaccharides could promote cancer cell apoptosis by stimulating macrophages and T cells to secrete cytokines, including IL-1, IL-6, TNF – α and IFN – γ. The fact that Ganoderma lucidum polysaccharide can enhance immunity was discovered.

The following picture is one of the evidences put forward by scientists at that time: the red part is leukemic cells. Compared with the cancer cells on the left (figures a and C), the cancer cells on the right (figures B and D) have appeared apoptosis. The reason for their apoptosis is that Ganoderma lucidum polysaccharide (PS-G) stimulates the secretion (containing the above-mentioned fine particles) produced by macrophages and T cells Cytokine).

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Ganoderma lucidum polysaccharides enhance immunity

In fact, the immune system in dealing with cancer cells and virus infection, using almost the same set of methods. Up to now, through the relay of scientists from all over the world, the mechanism of Ganoderma lucidum polysaccharides regulating the immune system has been explored more clearly.

In the review paper published in 2019 by Professor Lin Zhibin of Peking University, the key points of “immune regulation mechanism of Ganoderma lucidum polysaccharides” known in Science in the past 50 years are shown in schematic diagram

Whether it’s macrophages, natural killer cells, dendritic cells, T cells, or B cells that are responsible for producing specific antibodies, they will be upgraded by the intervention of Ganoderma lucidum polysaccharides.

The immunity initiated by Ganoderma lucidum can be said to be comprehensive, and all the immune responses required for anti-virus are taken into account.

Mechanism of Ganoderma lucidum extract powder enhancing immunity

Why does Ganoderma lucidum extract powder ( include ganoderma lucidum spore oil and polysaccharides ) have a way to upgrade the defense of the immune system? There are two answers that have been confirmed by science

Ganoderma lucidum polysaccharide will not be decomposed by digestive enzymes of gastrointestinal tract (so it will not produce heat), but it is the favorite “food” of some beneficial bacteria in intestinal tract. The substances (such as short chain fatty acids) secreted by these bacteria in the process of decomposing reishi mushroom extract powder  have the function of regulating immunity.

Moreover, in addition to intestinal bacteria, 70% of the immune cells in the human body are also distributed here. Ganoderma lucidum polysaccharides can bind to a variety of receptors on immune cells, including TLR-4, Mr, Dectin-1, CR3, etc. (as shown in the figure below). Once combined, it can activate immune cells, promote cytokine secretion, and bring the whole immune system from loose to alert state.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Ganoderma lucidum polysaccharide can reduce the number of new coronavirus infection in animal lungs

Research published in the latest issue of proceedings of the National Academy of Sciences has confirmed that Ganoderma lucidum polysaccharides can not only inhibit the proliferation of new coronavirus replication in cells, but also significantly reduce the number of pulmonary viruses in infected animals.

In this study, hamsters with respiratory tract tissue similar to human were used as the experiment: hamsters were infected with new coronavirus, and then Ganoderma lucidum polysaccharide extract was given orally at a daily dose of 200 mg / kg. After 3 days, the number of virus in their lungs was shown in the figure below, which was only half of that in the control group (without any drug).

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Ganoderma lucidum polysaccharides for the overall improvement of immunity, really help to fight against the new coronavirus. At this time, if we can add new crown vaccine and Ganoderma lucidum triterpenoids (such as Ganoderma lucidum acid A, Ganoderma lucidum acid B, Ganoderma lucidum acid C1, Ganoderma lucidum ketotriol, etc.) which can inhibit the proliferation of virus and inhibit excessive inflammatory reaction, we will certainly have more chips to fight against the epidemic.

The virus will not disappear, and it will continue to change. Therefore, we must be more careful to maintain immunity in order to coexist peacefully with the virus.

I hope that Ganoderma lucidum polysaccharides and Ganoderma lucidum triterpenoids like the products of ganoderma lucidum spore oil softgel have highly triterpenoids, which have accumulated scientific evidence for 50 years, can be the best backing for you and me to enhance immunity and fight against viruses.

Because only by fully activating immunity can we make the vaccines more powerful and make up for the inadequacy of vaccines. More information for Good Vaccine Needs Match With Good Ganoderma Lucidum, please check here. http://www.ncbi.nlm.nih.gov

Reference:

1. Takuma Sasaki, et al. Antitumor polysaccharides from some polyporaceae, Ganoderma applanatum (Pers.) Pat and Phellinus linteus (Berk. Et Curt) Aoshima. Chem Pharm Bull. 1971, 19(4): 821-826.

2. Sheng-Yuan WANG, et al. The anti-tumor effect of Ganoderma lucidum is mediated by cytokines released from activated macrophages and T lymphocytes. Int J Cancer. 1997, 70(6):699-705. 

3. Xin Wang, Zhibin Lin. Immunomodulating Effect of Ganoderma (Lingzhi) and Possible Mechanism. Adv Exp Med Biol. 2019;1182:1-37.  doi: 10.1007/978-981-32-9421-9_1.

4. Jia-Tsrong Jan, et al. Identification of existing pharmaceuticals and herbal medicines as inhibitors of SARS-CoV-2 infection. PNAS February 2, 2021 118 (5) e2021579118.

5. Nakarin Suwannarach, et al. Natural Bioactive Compounds from Fungi as Potential Candidates for Protease Inhibitors and Immunomodulators to Apply for Coronaviruses. Molecules. 2020, 25(8): 1800. doi:10.3390/molecules25081800.

2021-03-22