Polygonum Cuspidatum Extract Resveratrol  50% 98%,4:1 10:1 20:1 and etc offered by a 17 years experienced cGMP manufacturer with warehosues in China

Latin Name:Polygonum cuspidatum Sieb.et Zucc
Material Original:China
Extracted Part: Root and Rootstock
Supported Purity: Polygonum Cuspidatum Extract Resveratrol  50% 98%,4:1 10:1 20:1 and etc

What is the Polygonum Cuspidatum 

Polygonum cuspidatum. also named Giant Knotweed ,Hu Zhang (Chinese name). It belongs one of
polygonaceae plants species. It can be found in Asia and North America and is used as folk
medicine in countries such as Japan and Korea. In China, Hu Zhang is usually used in
combination with other TCM herbs. The therapeutic uses of those Hu Zhang-containing
TCM prescriptions or formulations are for treating cough, hepatitis, jaundice, amenorrhea, leucorrhea,
arthralgia, burns and snake bites. Recent pharmacological and clinical studies have indicated that Hu
Zhang has antiviral, antimicrobial, anti-inflammatory, neuroprotective, and cardioprotective functions.
This review gives a summary of the reported therapeutic effects of the active compounds and the
different extracts of Hu Zhang.

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Polygonum cuspidatum Sieb. et Zucc. is a herbaceous perennial plant. It is a member of the genus
Polygonumin the family Polygonaceae, which grows in Asia and North America. In China, there are
about 80 species ofPolygonum used in TCM . Its dried root (Figure 1) is officially listed in the
Pharmacopoeia of the People’s Republic of China under the name “Hu Zhang” ; it is also used as
folk medicine in Japan and Korea. From the perspective of TCM theory, Hu Zhang is used to remove
jaundice and clear heat-toxin so as to promote blood circulation, dispel stasis, expel wind and
dampness, dissipate phlegm, and suppress cough. Therefore, Hu Zhang is commonly prescribed
by TCM practitioners for the treatment of cough, hepatitis, jaundice, amenorrhea, leucorrhoea,
arthralgia, hyperlipidemia scald and bruises, snake bites, and carbuncles

How to Polygonum Cuspidatum  Extract Actions in pharmacological

Composition analysis of Knotweed reveals it to be a vessel for resveratrol (as well as a few other
compounds structurally similar to resveratrol and may act in the same way) and Rheum emodin .Both
of them owned effective anti-oxidant function and good for Cardiovascular health and invigorate the
circulation, Relieve pain, anti-poison,anti- phlegm.  Pharmacological researches and clinical studies
have indicated that Hu Zhang extract and its major compounds possess antivirus, antimicrobial,
anti-inflammatory, neuroprotective, and cardioprotective activities

MIGU‘s  Specification Providing for Polygonum Cuspidatum 

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Function of the Polygonum Cuspidatum Extract  

A: Antiviral Activities
Researchers have explored the efficacy of Hu Zhang extracts against HBV in HepG2 2.2.15
human hepatoblastoma cell line by quantitative real-time polymerase chain reaction in search
of effective antiviral agents. The expressions of HBeAg and HBsAg were determined by
enzyme-linked immunosorbent assay. Results indicated that ethanol extract of Hu Zhang
could inhibit the production of HBV with an effective minimal dose of 10 μg/mL. Both water
and ethanol extracts of Hu Zhang significantly increased the expression of HBsAg, whereas
a higher dose of water extract (30 μg/mL) inhibited the expression of HBeAg. However, both
extracts showed some degree of cytotoxicity to the host cells . It is not known whether
the anti-HBV effect and cytotoxicity are due to the same compound or active fraction of the
extracts. Further chemical and biological analyses are required to purify the active component(s)
in Hu Zhang.

B: Antimicrobial Effects
Research has demonstrated that the ethanol extract of Hu Zhang and its active compound,
emodin, possess significant protective effects against V. vulnificus cytotoxicity and infection. It
was identified that ethanol extract of Hu Zhang and emodin could protect RAW 264.7 and Hela
cells from V. vulnificus-induced cytotoxicity in vitro. They could also inhibit V. vulnificus growth
and survival in seawater and heart infusion broth. Pretreatment of ethanol extract of Hu Zhang
(200 mg/kg) or emodin (20 mg/kg) can protect 8-week-old CD-1 mice infected with V. vulnificus
in vivo . This further suggests the antimicrobial activity of Hu Zhang.

C:Anti-Inflammatory Effects
Hu Zhang extract (standardized to contain 20% trans-resveratrol) demonstrated comprehensive
suppressive effects on inflammatory and oxidative stress. These effects are achieved through
decreasing levels of TNF-α, interleukin, intranuclear NFκB binding, c-jun-N-terminal kinase 1 (JNK 1),
phosphotyrosine phosphatase-1B (PTP-1B), as well as reactive oxygen species (ROS) generation in
mononuclear cells

Ethanolic solution of Hu Zhang and resveratrol were demonstrated to inhibit the development of
edema and leukocyte infiltration in the 12-O-tetradecanoylphorbol-13-acetate-(TPA-) induced
ear edema in mice in vivo.. Topical application of resveratrol also significantly inhibited TPA-induced
COX-2 expression via modulation of the IKK-NFκB signaling cascade in mouse skin in vivo. This
investigation provides evidence for the potential uses of Hu Zhang in cosmeceutical and dermatological
products

D: Neuroprotective Activities
Preventing neuronal death is a top priority for treating neurological diseases . Oxidative stress is
implicated as a causative factor in neuronal death in neurodegenerative disorders . There is a growing
interest in searching for neuroprotective agents from natural products since they contain compounds
with high antioxidant power . Several studies have reported the neuroprotective effects of Hu Zhang
extract or its major compounds such as polydatin, emodin 8-O-β-D-glucopyranoside,
2-methoxy-6-acetyl-7-methyljuglone, and resveratrol.

Senescence-accelerated mouse (SAM), an aging model, was used for brain aging and anti-aging
pharmacology studies. Resveratrol extracted from Hu Zhang increased the SOD and GPx activities,
while decreasing MDA level in SAM in vivo. Resveratrol could improve neuromuscular coordination
and sensorimotor ability in tightrope test. It could also enhance the learning and memory capacity
in Morris water maze test in SAM. These results indicate that resveratrol may exhibit therapeutic
potential for age-related conditions

E:Cardioprotective Activities
Resveratrol could also protect the heart from I/R injury, prevent cardiac hypertrophy in hypertensive
animals, and reduce the progression of atherosclerosis. It is believed that endothelial NOS, estrogen
receptor alpha (ERα), Akt kinase, NFκB, and survival activating factor enhancement pathway may
mediate the aforementioned cardiovascular effects of resveratrol . Resveratrol supplementation
elevated apo-AI/apo B ratio and levels of HDL-cholesterol, and decreased plasma LDL-C concentration
and hepatic HMG-CoA reductase activity. Moreover, in resveratrol-supplemented apo  mice,
ICAM-1 and VCAM-1 in atherosclerotic vessels were diminished, thereby delaying the progression
of atherosclerosis . Pretreated with resveratrol improved cardiac function and reducement
myocardial infarct size and cardiomyocyte apoptosis in the ischemic/reperfused rats heart.
Resveratrol protected the ischemic heart by restoring the IR-induced altered microRNA expressions .
All of the above findings suggest that polydatin and resveratrol are potential bioactive compounds for
treating cardiovascular diseases.

In addition, Hu Zhang’s methanolic extract and active compounds, such as emodin and emodin
8-O-β-D-glucopyranoside, were found to enhance the proliferation of MCF-7, an estrogen-sensitive
cell line, in a concentration-dependent manner. It was found that emodin exerts estrogen-like
activities by binding to human ERα and ERβ. It may be useful for hormone replacement therapy against
human menoxenia and post-menopausal diseases [53]. Citreorosein, a naturally occurring
anthraquinone derivative from Hu Zhang, was found to exert estrogenic activity by using a recombinant
assay

Three Hu Zhang’s anthraquinones, physcion, emodin, and citreorosein, showed moderate to strong
tyrosinase inhibition. Thus, they may be used as skin whitening agents in place of kojic acid. Among
these anthraquinones, physcion exhibited the most potent tyrosinase inhibition and showed higher
permeability into the skin, suggesting its potential in cosmeceutical and dermatological uses.

Our Planted base in GanSu,China 

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Conclusions
Polygonum Cuspidatum Extract has been prescribed in China for medical purposes for thousands of years. Reports in the
literature have demonstrated Polygonum Cuspidatum Extract’s potential beneficial effects such as antimicrobial, antiviral,
anti-inflammatory, estrogenic, neuroprotective, and cardioprotective activities. Yet, there is no research
reporting/investigating the toxicity of Polygonum Cuspidatum Extract. Based on the results from both clinical tests and research
tests conducted in laboratories, several active compounds of Polygonum Cuspidatum Extract have demonstrated positive
effects on a variety of diseases. Polygonum Cuspidatum Extract might be a valuable alternative medicine that could be
integrated into conventional treatments. More researches on the beneficial effects of Polygonum Cuspidatum Extract and its
potential risks as an alternative medicine are needed. More Scientific research and development , please check here